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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1992 2
1994 4
1995 5
1996 3
1997 12
1998 19
1999 19
2000 30
2001 32
2002 28
2003 45
2004 56
2005 72
2006 81
2007 88
2008 94
2009 94
2010 88
2011 105
2012 122
2013 150
2014 154
2015 182
2016 189
2017 181
2018 204
2019 180
2020 179
2021 190
2022 173
2023 142
2024 62

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2,631 results

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Page 1
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics.
Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, Barrea L, Hassan STS, Šmejkal K, Malaník M, Sychrová A, Barreca D, Ziberna L, Mahomoodally MF, Zengin G, Xu S, Nabavi SM, Shen AZ. Feng X, et al. Theranostics. 2019 Mar 16;9(7):1923-1951. doi: 10.7150/thno.30787. eCollection 2019. Theranostics. 2019. PMID: 31037148 Free PMC article. Review.
Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. ...Recent discoveries of basic, translational and clinical studies have identified many novel molecular target …
Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to d …
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease.
Marais AD. Marais AD. Pathology. 2019 Feb;51(2):165-176. doi: 10.1016/j.pathol.2018.11.002. Epub 2018 Dec 28. Pathology. 2019. PMID: 30598326 Review.
ApoE2 generally is most favourable and apoE4 least favourable for cardiovascular and neurological health. The apoE variants relate to different amino acids at positions 112 and 158: cysteine in both for apoE2, arginine at both sites for apoE4, and respectively cysteine and …
ApoE2 generally is most favourable and apoE4 least favourable for cardiovascular and neurological health. The apoE variants relate to …
Genetic and molecular architecture of familial hypercholesterolemia.
Abifadel M, Boileau C. Abifadel M, et al. J Intern Med. 2023 Feb;293(2):144-165. doi: 10.1111/joim.13577. Epub 2022 Oct 17. J Intern Med. 2023. PMID: 36196022 Free PMC article. Review.
Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its important risk of premature atherosclerosis and cardiovascular disease, familial hypercholesterolemia (FH) is still largely underdiagnosed worldwide. It is one of the most fre …
Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its important risk of premature atherosclerosi …
Animal models of atherosclerosis.
Emini Veseli B, Perrotta P, De Meyer GRA, Roth L, Van der Donckt C, Martinet W, De Meyer GRY. Emini Veseli B, et al. Eur J Pharmacol. 2017 Dec 5;816:3-13. doi: 10.1016/j.ejphar.2017.05.010. Epub 2017 May 5. Eur J Pharmacol. 2017. PMID: 28483459 Free article. Review.
Both Apolipoprotein E deficient (ApoE(-/-)) and LDL-receptor (LDLr) knockout mice have been frequently used, but also ApoE/LDLr double-knockout, ApoE3-Leiden and PCSK9-AAV mice are valuable tools in atherosclerosis research. ...
Both Apolipoprotein E deficient (ApoE(-/-)) and LDL-receptor (LDLr) knockout mice have been frequently used, but also ApoE/LDLr …
Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits.
Glicksberg BS, Amadori L, Akers NK, Sukhavasi K, Franzén O, Li L, Belbin GM, Ayers KL, Shameer K, Badgeley MA, Johnson KW, Readhead B, Darrow BJ, Kenny EE, Betsholtz C, Ermel R, Skogsberg J, Ruusalepp A, Schadt EE, Dudley JT, Ren H, Kovacic JC, Giannarelli C, Li SD, Björkegren JLM, Chen R. Glicksberg BS, et al. BMC Med Genomics. 2019 Jul 25;12(Suppl 6):108. doi: 10.1186/s12920-019-0542-3. BMC Med Genomics. 2019. PMID: 31345219 Free PMC article.
We integrated the analysis of genetic and clinical data from 10,511 individuals in the Mount Sinai BioMe Biobank to identify genes with loss-of-function variants (LoFs) significantly associated with cardiovascular disease (CVD) traits, and used RNA-sequence data of seven m …
We integrated the analysis of genetic and clinical data from 10,511 individuals in the Mount Sinai BioMe Biobank to identify genes with loss …
Lipoprotein receptor signalling in atherosclerosis.
Mineo C. Mineo C. Cardiovasc Res. 2020 Jun 1;116(7):1254-1274. doi: 10.1093/cvr/cvz338. Cardiovasc Res. 2020. PMID: 31834409 Free PMC article. Review.
The founding member of the lipoprotein receptor family, low-density lipoprotein receptor (LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis of LDL particles and regulation of cholesterol homeostasis. ...Human genetics of the receptors …
The founding member of the lipoprotein receptor family, low-density lipoprotein receptor (LDLR) plays a major role in the atherogenes …
Mouse models of atherosclerosis in translational research.
Ilyas I, Little PJ, Liu Z, Xu Y, Kamato D, Berk BC, Weng J, Xu S. Ilyas I, et al. Trends Pharmacol Sci. 2022 Nov;43(11):920-939. doi: 10.1016/j.tips.2022.06.009. Epub 2022 Jul 25. Trends Pharmacol Sci. 2022. PMID: 35902281 Review.
Atherosclerotic cardiovascular disease (CVD), the major cause of premature human mortality, is a chronic and progressive metabolic and inflammatory disease in large- and medium-sized arteries. ...We review the current preclinical utility and translation potential of tradit …
Atherosclerotic cardiovascular disease (CVD), the major cause of premature human mortality, is a chronic and progressive metabolic an …
Small rodent models of atherosclerosis.
Zhao Y, Qu H, Wang Y, Xiao W, Zhang Y, Shi D. Zhao Y, et al. Biomed Pharmacother. 2020 Sep;129:110426. doi: 10.1016/j.biopha.2020.110426. Epub 2020 Jun 20. Biomed Pharmacother. 2020. PMID: 32574973 Free article. Review.
The advent of transgenic technologies much supports animal models' establishment. Notably, two classic transgenic mouse models, apoE-/- and Ldlr-/-, constitute the primary platforms for studying underlying mechanisms and development of pharmaceutical approaches. ...Studies …
The advent of transgenic technologies much supports animal models' establishment. Notably, two classic transgenic mouse models, apoE-/- and …
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank.
Jurgens SJ, Choi SH, Morrill VN, Chaffin M, Pirruccello JP, Halford JL, Weng LC, Nauffal V, Roselli C, Hall AW, Oetjens MT, Lagerman B, vanMaanen DP; Regeneron Genetics Center; Aragam KG, Lunetta KL, Haggerty CM, Lubitz SA, Ellinor PT. Jurgens SJ, et al. Nat Genet. 2022 Mar;54(3):240-250. doi: 10.1038/s41588-021-01011-w. Epub 2022 Feb 17. Nat Genet. 2022. PMID: 35177841 Free PMC article.
Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these diseases remains incomplete. Here, we analyzed the contribution of rare variants to 57 diseases and 26 cardiometabolic traits, usi …
Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these d …
2,631 results